Deep Dive into Reproduction with LIFE by Dr. Pat
Deep dive into reproduction and fertility treatment by LIFE by Dr. Pat Clinic and Dr. Patsama Vichinsartvichai
Deep Dive into Reproduction with LIFE by Dr. Pat
The Chronic Endometritis Conundrum: Does Treating CD138 Really Fix Recurrent Implantation Failure?
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When beautiful, high-grade embryos repeatedly fail to implant, both patients and clinicians are desperate for answers, and chronic endometritis has quickly become the go-to culprit to hunt down and treat. But before jumping straight to weeks of antibiotics or intrauterine infusions, we have to look at what the broader evidence actually tells us. In this episode, Dr. Patsama dives into a comprehensive 2026 systematic review covering 24 studies on recurrent implantation failure (RIF). While a course of antibiotics clears up those CD138 plasma cells under the microscope in the majority of cases, whether that histological "cure" actually boosts your chances of a clinical pregnancy or a live baby remains frustratingly uncertain. Join us for a candid, reassuring chat as we unpack the wild swings in how chronic endometritis is diagnosed (with prevalence estimates ranging anywhere from 7% to 64%), why embryonic chromosomal factors are still the elephant in the room that most studies completely ignore, and how to navigate testing without getting lost in the overmedication trap.
